Jesse T. Kaye, PhD
Assistant Professor
he/him
Education
- University of Wisconsin–Madison – PhD, Clinical Psychology
- William S. Middleton Memorial Veterans Hospital – VA Clinical Psychology Internship
- William S. Middleton Memorial Veterans Hospital – VA Advanced Addiction Treatment/Research Fellowship
Bio
Jesse Kaye, PhD, is an Assistant Professor in the University of Wisconsin Department of Family Medicine and Community Health and the UW Center for Tobacco Research and Intervention. Kaye’s research on tobacco, cannabis, and other substance use disorders focuses on processes related to risk, etiology, and treatment for addictive disorders. An overarching goal of his research has been to develop more effective smoking treatments for populations disproportionately affected by tobacco use such as those with mental illness, heavy alcohol or cannabis use, socioeconomic disadvantage, incarceration, or cancer.
Kaye’s research and outreach focus on dissemination and implementation of evidence-based tobacco treatments within healthcare, community, and digital systems. He has a growing program of interdisciplinary research on cannabis science and particularly the intersection of cannabis and tobacco co-use as it relates to tobacco dependence and treatment.
Kaye’s current National Institutes of Health K23 Career Development Award will support a program of research applying machine learning approaches to inform personalized treatment selection, identify periods of heightened lapse risk, and implement just-in-time adaptive interventions (JITAI) to avert smoking lapses and improve long term smoking cessation success. This research aims to use prospective risk predictions machine learning models to develop novel digital personalized feedback interventions that reduce lapse and relapse likelihood by providing the right treatment, for the right person, at the right time.
Kaye’s research incorporates a diverse methodological toolbox, including human lab studies (psychophysiology), psychotherapy and medication clinical trials (mechanistic and treatment-oriented research), collection and analysis of intensive longitudinal data (ecological momentary assessment), qualitative methods, population surveys, and psychometric evaluation.
Kaye is an academic editor at PLOS One and has a demonstrated commitment to open science principles promoting scientific rigor, robustness, and reproducibility in his work and the field at large.
Research Interests
Kaye is a clinical psychologist and scientist. His research interests include:
- Tobacco, cannabis, and other substance use disorder development, maintenance, and health consequences
- Tobacco treatment development, dissemination, and implementation
- Tobacco treatment in patient populations (e.g., cancer, behavioral health)
- Harm reduction
- Personalized and precision medicine
Publications and Presentations
My Bibliography and ORCID
- Kaye JT, Piasecki TM, Fiore MC, et al. Reach, Acceptability, and Effectiveness of Proactive Outreach and Varenicline with Cancer-Focused Counseling for Patients with Cancer: A Pilot Randomized Comparative Effectiveness Trial. JCO Oncol Adv. 2026;3:e2500169. doi:10.1200/oa-25-00169
- Kaye JT, Kathuria H. Rethinking Smoking: Cannabis, Tobacco, and Lung Cancer. Chest. 2026;169(3):586-588. doi:10.1016/j.chest.2025.11.014
- Kaye JT, Kirsch JA, Bolt DM, et al. Tobacco Quitline Retreatment Interventions Among Adults With Socioeconomic Disadvantage: A Factorial Randomized Clinical Trial. JAMA Netw Open. 2024;7(11):e2443044. Published 2024 Nov 4. doi:10.1001/jamanetworkopen.2024.43044
- Williams BS, Kaye JT. Vaping Cessation Methods Used by Adolescents. JAMA Pediatr. 2025;179(9):1043-1044. doi:10.1001/jamapediatrics.2025.1974
- Kaye JT, Kirsch JA, Bolt DM, et al. Tobacco Quitline Retreatment Interventions Among Adults With Socioeconomic Disadvantage: A Factorial Randomized Clinical Trial. JAMA Netw Open. 2024;7(11):e2443044. Published 2024 Nov 4. doi:10.1001/jamanetworkopen.2024.43044
Awards and Honors
- K23 Career Development Award (2025-2030) – National Institute of Drug Abuse