PROTEA Publications - (Program for Research, Outreach, Therapeutics, and Education in the Addictions)

2024

Nicholas, C.R., Banks, M.I., Lennertz, R.C. et al. Co-administration of midazolam and psilocybin: differential effects on subjective quality versus memory of the psychedelic experience. Transl Psychiatry 14, 372 (2024). https://doi.org/10.1038/s41398-024-03059-8

O’Donnell KC, Okano L, Alpert M, Nicholas CR, Thomas C, Poulter B, Mithoefer A, Mithoefer M, Ot’alora G M. The conceptual framework for the therapeutic approach used in phase 3 trials of MDMA-assisted therapy for PTSD. Front Psychol. 2024 Nov 4;15:1427531. doi: 10.3389/fpsyg.2024.1427531. PMID: 39559692; PMCID: PMC11571099.

2023

Brett J, Knock E, Korthuis PT, Liknaitzky P, Murnane KS, Nicholas CR, Patterson JC II and Stauffer CS (2023) Exploring psilocybin-assisted psychotherapy in the treatment of methamphetamine use disorder. Front. Psychiatry 14:1123424. https://doi.org/10.3389/fpsyt.2023.1123424

Raison, C. L., Sanacora, G., Woolley, J., Heinzerling, K., Dunlop, B. W., Brown, R. T., Kakar, R., Hassman, M., Trivedi, Rupal P. Robison, R., Gukasyan, N., Nayak, S.M., Hu, X., O’Donnell, K.C., Kelmendi, B., Sloshower, J., Penn, A.D., Bradley, E., Kelly, D.F., Mletzko, T., Nicholas, C.R., Hutson, P. R. Tarpley, G., Utzinger, M., Lenoch, K. Warchol, K., Gapasin, T., Davis, M. C., Nelson-Douthit, C., Wilson, S., Brown, C., Linton, W., Ross, S., Griffiths, R. R. & Griffiths, R. R. Single-dose psilocybin treatment for major depressive disorder: A randomized clinical trial. Journal of the American Medical Association (JAMA). New Online.

Mitchell, J. M., Ot’alora G, M., van der Kolk, B., Bogenschutz, M., Yevgeniy, G., Paleos, C., Nicholas, C.R., Quevedo, S., Balliett, B., Hamilton, S., Mithoefer, M., Kleiman, S., Parker-Guilbert, K., Tzarfaty, K., Harrison, C., De Boer, A., Doblin, R., Yazar-Klosinski, B. MDMA-assisted therapy for Moderate to Severe PTSD: A Randomized, Placebo-Controlled Phase 3 Trial. Nature Medicine, 2023; Accessed online on September 14, 2023. https://doi.org/10.1038/s41591-023-02565-4

2022

Tilhou, A.S., Birstler, J., Baltes, A. et al. Characteristics and context of fentanyl test strip use among syringe service clients in southern Wisconsin. Harm Reduct J 19, 142 (2022). https://doi.org/10.1186/s12954-022-00720-7

Nicholas, C. R., Wang, J. B., Coker, A., Mitchell, J. M., Klaire, S. S., Yazar-Klosinski, B., Emerson, A., Brown, R. T., & Doblin, R. (2022). The effects of MDMA-assisted therapy on alcohol and substance use in a phase 3 trial for treatment of severe PTSD. Drug and alcohol dependence, 233, 109356. https://doi.org/10.1016/j.drugalcdep.2022.109356

Brown, R. T., Deyo, B., Nicholas, C., Baltes, A., Hetzel, S., Tilhou, A., Quanbeck, A., Glass, J., O’Rourke, A., & Agarwal, S. (2022). Screening in Trauma for Opioid Misuse Prevention (STOMP): Results from a prospective cohort of victims of traumatic injury. Drug and alcohol dependence, 232, 109286. https://doi.org/10.1016/j.drugalcdep.2022.109286

2021

David H Gustafson Sr,; Marie-Louise Mares; Darcie C Johnston; Jane E Mahoney; Randall Brown; Gina Landucci; Klaren Pe-Romashko, Olivia J Cody; David H Gustafson Jr, ; Dhavan V Shah. A Web-Based eHealth Intervention to Improve the Quality of Life of Older Adults With Multiple Chronic Conditions: Protocol for a Randomized Controlled Trial. JMIR Research Protocols. 2021; 10(2): e25175.

Abraham, O, Szela, L, Thakur, T, Brasel, K, Brown, R. Adolescents perspectives on prescription opioid misuse and medication safety. J Pediatr Pharmacol Ther. 2021;26(2):133-143.

Salisbury-Afshar E, Kauppila G. Alcoholics Anonymous and Other 12-Step Facilitation Programs for Alcohol Use Disorder. American Family Physician. 2021 Mar 1;103(5):272-273.

Mitchell, Jennifer M., Michael Bogenschutz, Alia Lilienstein, Charlotte Harrison, Sarah Kleiman, Kelly Parker-Guilbert, Wael Garas et al. “MDMA-assisted therapy for severe PTSD: a randomized, double-blind, placebo-controlled phase 3 study.” Nature Medicine 27, no. 6 (2021): 1025-1033.

2020

Nora Jacobson, PhD; Julie Horst; Liam Wilcox-Warren; Alex Toy; Hannah Knudsen; Randy Brown; Eric Haram; Lynn Madden; Todd Molfenter. Organizational Facilitators and Barriers to Medications to Treat Opioid Use Disorders (MOUD) Capacity Expansion and Use. The Journal of Behavioral Health Services & Research. 2020 April.

Abraham O, Thakur T, Brown R. Developing a Theory-Driven Serious Game to Promote Prescription Opioid Safety Among Adolescents: Mixed Methods Study. JMIR Serious Games 2020;8(3):e18207 PMID: 32618571

Jacobson N, Horst J, Wilcox-Warren L, Toy A, Knudsen HK, Brown R, Haram E, Madden L, Molfenter T. Organizational Facilitators and Barriers to Medication for Opioid Use Disorder Capacity Expansion and Use. J Behav Health Serv Res. 2020 Oct;47(4):439-448. doi: 10.1007/s11414-020-09706-4. PMID: 32347426; PMCID: PMC7578054.

Quanbeck A, Almirall D, Jacobson N, Brown RT, Landeck JK, Madden L, Cohen A, Deyo BM, Robinson J, Johnson RA, Schumacher N. The Balanced Opioid Initiative: protocol for a clustered, sequential, multiple-assignment randomized trial to construct an adaptive implementation strategy to improve guideline-concordant opioid prescribing in primary care. Implementation Science. 2020 Dec;15:1-3.

Abraham, O, LeMay, S, Bittner, S, Thakur, T, Stafford, H, Brown, R. Investigating serious games that incorporate medication use for patients: a systematic literature review. JMIR Serious Games (2020). doi:10.2196/16096.

Derefinko, KJ., Brown RT, Danzo A, Foster S, Brennan T, Hand S, and Kunz K. Addiction Medicine Training Fellowships in North America: A Recent Assessment of Progress and Needs. Journal of Addiction Medicine (2020).

Goldberg, SB, Schehet, B, Nicholas, CR, Ng, Chi Wing, Deole, G, Chen,Zhuofan , & Raison, C. (2020). Post-acute psychological effects of classical serotonergic psychedelics: A systematic review and meta-analysis., Psychological Medicine, (2020).

2019

Goldberg, S., Pace, B., Nicholas, C. R., Raison, C., Hutson, P. (2019). The experimental effects of psilocybin on symptoms of anxiety and depression: A meta-analysis, Psychiatry Research, 284, 112749.

Knudsen HK, Brown R, Jacobson N, Horst J, Kim JS, Collier E, Starr S, Madden LM, Haram E, Molfenter T. Pharmacotherapy, resource needs, and physician recruitment practices in substance use disorder treatment programs. Journal of addiction medicine. 2019 Jan;13(1):28.

Brellenthin AG, Crombie KM, Hillard CJ, Brown RT, Koltyn KF. Psychological and endocannabinoid responses to aerobic exercise in substance use disorder patients. Substance abuse. 2019 Nov 15:1-2.. 2019.

Knudsen, HK., Brown RT, Jacobson N, Horst J, Kim JS, Collier E, Starr S et al. Physicians’ satisfaction with providing buprenorphine treatment. Addiction science & clinical practice 14, no. 1 (2019): 1-7.

Baltes A, Deyo B, Kaiser M, Birstler J, Brown R. Survey of Southern Wisconsin Needle Exchange Clients Regarding Opioid Overdose and Naloxone Use. Wisconsin State Medical Journal. 2019; 118(2): 84-87.

Abraham, O., Thakur, T., & Brown, R. (2019). Prescription opioid misuse and the need to promote medication safety among adolescents. Research in Social and Administrative Pharmacy. 2019; 15(7): 841-844. PMID: 30655180

2018

Nicholas CR, Henriquez KM, Gassman MC, Cooper KM, Muller D, Hetzel S, Brown RT, Cozzi NV, Thomas C, Hutson PR. High dose psilocybin is associated with positive subjective effects in healthy volunteers. Journal of Psychopharmacology. 2018 Jul;32(7):770-8. PMID: 29945469

Smith, J. C., Nicholas, C. R., Hetzel, S. J., Deyo, B. M., & Brown, R. T. (2018). Associations between pain coping and opioid use: One-month follow-up results of a prospective study in a cohort of traumatic injury patients. Journal of Opioid Management, 14(3), 159-163. PMID: 30044480

Chouinard S, Prasad A, Brown R. Survey Assessing Medical Student and Physician Knowledge and Attitudes Regarding the Opioid Crisis. Wisconsin Medical Journal. 2018 March; 117(1): 34-37. PMID: 29677413.

Quanbeck A, Gustafson D, Marsch LA, Chih MY, Cornfield R, McTavish F, Johnson R, Brown RT, et al. Implementing a Mobile Health System to Integrate the Treatment of Addiction into Primary Care: A Hybrid Implementation-Effectiveness Study. Journal of Medical Internet Research. 2018 Jan 30;20(1):e37. PMCID: PMC5811649.

Quanbeck A, Brown RT, Zgierska AE, Jacobson N, Robinson JM, et al. A randomized matched-pairs study of feasibility, acceptability, and effectiveness of systems consultation: a novel implementation strategy for adopting clinical guidelines for Opioid prescribing in primary care. Implementation Science. 2018 Jan 25;13(1):21. PMCID: PMC5784593.

Alagoz E, Chih MY, Hitchcock ME, Brown R, Quanbeck A. The use of external change agents to promote quality improvement and organizational change in healthcare organizations: A systematic review. BMC Health Services Research. 2018 Jan 25;18(1):42. PMCID: PMC5785888.

2017

Molfenter T, Knudsen HK, Brown R, Jacobson N, Horst J, et al. Test of a workforce development intervention to expand opioid use disorder treatment pharmacotherapy prescribers: protocol for a cluster randomized trial. Implementation Science. 2017 Nov 15;12(1):135. PMCID: PMC5688699.

Brown R, Deyo B, Riley C, Glass J, Turpin R, et al. Screening in Trauma for Opioid Misuse Prevention (STOMP): Study Protocol for the Development of an Opioid Risk Screening Tool for Victims of Injury. Addiction Science & Clinical Practice. 2017 Dec 4;12(1):28. PMCID: PMC5713647.

Harris AHS, Brown R, Dawes M, Dieperink E, Myrick DH, et al. Effects of a Multifaceted Implementation Intervention to Increase Utilization of Pharmacological Treatments for Alcohol Use Disorders in the US Veterans Health Administration. Journal of Substance Abuse Treatment. 2017 Nov;82:107-112. PMID: 29021108.

Busch AC, Denduluri M, Glass J, Hetzel S, Gugnani SP, Gassman M, Krahn D, Deyo B, Brown RT. Pre-discharge injectable vs. oral naltrexone to improve post-discharge treatment engagement among hospitalized veterans with alcohol use disorder: A pilot proof-of-concept study. Alcoholism: Clinical & Experimental Research. 2017 Jul;41(7):1352-1360. PMCID: PMC5519139.

Brown RT, Nicholas CR, Cozzi NV, Gassman MC, Cooper KM, et al. Pharmacokinetics of Escalating Doses of Oral Psilocybin in Healthy Adults. Clinical Pharmacokinetics. 2017 Dec;56(12):1543-1554. PMID: 28353056.

2016

Hofer HM, Deyo BM, Mills JP, Kloke JD, Cruz LC, Brown RT. Opioid-related risk screening in Wisconsin pharmacies: current practices and barriers to expansions. The Journal of the Pharmacy Society of Wisconsin. Sept-Oct, 2016: 19(5):49-53.

Mares ML, Gustafson DH, Glass JE, Quanbeck A, McDowell H, McTavish F, Atwood AK, Marsch LA, Thomas C, Shah D, Brown R, et al. Implementing an mHealth system for substance use disorders in primary care: A mixed methods study of clinicians’ initial expectations and first year experiences. BMC Medical Informatics and Decision Making. 2016 Sep 29;16(1):126. PMCID: PMC5043521.

Brown R, Wright N, Deyo B, Baltes A, Linden M, Szela L. Addressing the crime reduction and harm reduction divide: promoting opioid agonist therapy in the US drug courts. Internal Medicine Review. 2016:2(5):49-53.

Leslie LK, Mehus CJ, Hawkins JD, Boat T, McCabe MA, Barkin S, Perrin EC, Metzler C, Prado G, Tait VF, Brown R, et al. Primary health care: potential home for family-focused preventive interventions. American Journal of Preventative Medicine. 2016 Oct;51(4 Suppl 2):S106-18. PMCID: PMC5406159.

Hagedorn H, Brown R, Dawes M, Dieperink E, Myrick D, et al. Enhancing access to alcohol use disorder pharmacotherapy and treatment in primary care settings: ADaPT-PC. Implementation Science. 2016 May 10: 11(1):64. PMCID: PMC4862158.

Quanbeck A, Brown RT, E Zgierska A, A Johnson R, Robinson JM, et al. Systems consultation: protocol for a novel implementation strategy designed to promote evidence-based practice in primary care. Health Research Policy and Systems. 2016 Jan 27;14(1):8. PMCID: PMC4729135.

Glass JE, Hamilton AM, Powell BJ, Perron BE, Brown RT, et al. Revisiting our review of Screening, Brief Intervention and Referral to Treatment (SBIRT): meta-analytical results still point to no efficacy in increasing the use of substance use disorder services. Addiction. 2016 Jan;111(1):181-3. PMID: 26464318

Leslie, LK, Mehus CJ, Hawkins JD, Boat T, MA, Barkin S, Perrin EC, Brown RT, Beardsley W. “Primary Health Care: Realizing Population-Level Improvement for All Children’s Cognitive, Affective, and Behavioral Health, “ American Journal of Preventive Medicine, 2016; 51 (4): S106–18. PMCID: PMC5406159.

2015

Glass JE, Hamilton AM, P Powell BJ, Perron BE, Brown RT, Ilgen MA. Specialty substance use disorders following brief alcohol intervention: a meta-analysis of randomized controlled trials. Addiction. 2015 Sep;110(9):1404-15. PMCID: PMC4753046.

2014

Quanbeck A, Gustafson D, Marsch L, McTavish F, Brown RT, Mares M, Johnson R, Glass J, Atwood A, McDowell H. Integrating addiction treatment into primary care using mobile health technology: protocol for an implementation research study. Implementation Science. 2014; 9: 65-76. PMCID: PMC4072605.

2013

Brown RT, Gassman M, Hetzel S, Berger L. Community-based treatment for opioid dependent offenders: a pilot study. American Journal on Addictions. 2013; 22:500–502. PMCID: PMC3748386.

Brown RT, Gassman M. Assistant district attorney decision making when referring to drug treatment court. American Journal on Addictions. 2013; 22(4), 381-387. PMID: 23795878.

2011

Brown RT, Allison PA, Nieto FJ. Impact of jail sanctions during drug court participation upon substance abuse treatment completion. Addiction. 2011; 106(1):135-142. PMCID: PMC3057754.

Brown RT. Drug court effectiveness: a matched cohort study in the Dane County drug treatment court. Journal of Offender Rehabilitation. 2011; 50(4):191-201.

2010

Brown R. Associations with substance abuse treatment completion among drug court participants. Substance Use and Misuse. 2010; 45(12):1874- 1891. PMCID: PMC2925283.

Brown RT. Systematic review of the impact of adult drug treatment courts. Translational Research. 2010; 155(6):263-274. PMCID: PMC2886018.

2009

Brown RT, Zuelsdorff M. Treatment retention among African-Americans in the Dane County Drug Treatment Court. Journal of Offender Rehabilitation. 2009 May; 48(4):336-349. PMCID: PMC2882705

2007

Zgierska A, Brown RT, Zuelsdorff M, et al. Sleep and daytime sleepiness problems among patients with chronic noncancerous pain receiving long-term opioid therapy: A cross-sectional study. Journal of Opioid Management. 2007; 3(6):317-327. PMID: 18290583

Miller MM, Brown RT. Prescription drug monitoring programs. American Family Physician. 2007; 75(6):810-811. PMID: 17390593

Brown RT, Brown RL. Primary care assessment and management of chronic non-cancer pain. MedEdPORTAL; 2007 July.

Brown RT, Zuelsdorff M. Opioid substitution with methadone and buprenorphine: Sexual dysfunction as a side effect of therapy. Heroin Addiction and Related Clinical Problems. 2007; 9(1):35-44.

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